Atropisomeric 9,10-dihydrophenanthrene/bibenzyl trimers with anti-inflammatory and PTP1B inhibitory activities from <i>Bletilla striata</i>
Mo-Han Sun, Xian-Jie Ma, Si-Yuan Shao, Jianwei Jiang, Jia’an Li, Jin‐Ying Tian, Jianjun Zhang, Li Li, Fei Ye, Shuai Li
Abstract
Two pairs of novel trimeric dihydrophenanthrene–bibenzyl–dihydrophenanthrene enantiomers, together with three rare polymers were isolated from Bletilla striata . Some compounds showed significant anti-inflammatory and PTP1B inhibitory activities.
Topics & Concepts
BibenzylChemistryStereochemistryEnantiomerDimerAtropisomerChirality (physics)Two-dimensional nuclear magnetic resonance spectroscopyMethylene bridgeMoietyOrganic chemistryChiral symmetry breakingPhysicsNambu–Jona-Lasinio modelQuarkQuantum mechanicsBiological and pharmacological studies of plantsPhytochemistry and Biological ActivitiesGinseng Biological Effects and Applications