Black bean husk and black rice anthocyanin extracts modulated gut microbiota and serum metabolites for improvement in type 2 diabetic rats
Mubai Sun, Da Li, Hua Mei, Xinyu Miao, Ying Su, Yanping Chi, Yueqiao Li, Ruiyue Sun, Honghong Niu, Jinghui Wang
Abstract
spp., changed the gut microbiota structure; activated AMPK, PI3K, and AKT; inhibited HMGCR, G6pase and PEPCK expression; and inhibited hepatic gluconeogenesis. Moreover, by adjusting the levels of urea, deoxycytidine, L-citrulline, pseudouridine, and other serum metabolites in T2DM rats, the arginine biosynthesis and pyrimidine metabolism pathways were downregulated. The above results indicated that black rice and black bean husk anthocyanin extracts had a significant impact on the development of T2DM.
Topics & Concepts
Black riceAnthocyaninHuskBiologyLipid metabolismBiochemistryFood scienceChemistryBotanyRaw materialEcologyGut microbiota and healthMetabolomics and Mass Spectrometry StudiesTea Polyphenols and Effects