Umpolung coupling of pyridine-2-carboxaldehydes and propargylic carbonates <i>via</i> N-heterocyclic carbene/palladium synergetic catalysis
Weiyang Bi, Yunhui Yang, Song Ye, Congyang Wang
Abstract
The umpolung cross-coupling reaction of pyridine-2-carboxaldehydes and propargylic carbonates has been developed for the first time through N-heterocyclic carbene/palladium cooperative catalysis with the judicious selection of the palladium catalyst, ligand and N-heterocyclic carbene, giving the propargylic ketones regioselectively.
Topics & Concepts
UmpolungPalladiumCatalysisCarbeneChemistryPyridineCoupling (piping)Combinatorial chemistryMedicinal chemistryPhotochemistryOrganic chemistryMaterials scienceMetallurgyNucleophileCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsCatalytic Alkyne Reactions