Single-shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad, durable and protective systemic and mucosal immunity in mice
Nicholas You Zhi Cheang, Kai Sen Tan, Peck Szee Tan, Kiren Purushotorma, Wee Chee Yap, Kirsteen M. Tullett, Benson Yen Leong Chua, Aileen Ying-Yan Yeoh, Caris Qi Hui Tan, Xinlei Qian, Huixin Chen, Douglas Jie Wen Tay, Irina Caminschi, Yee‐Joo Tan, Paul Anthony Macary, Chee Wah Tan, Mireille H. Lahoud, Sylvie Alonso
Abstract
decrease in lung viral loads compared with non-immunized controls. Therefore, Clec9A-RBD immunization has the potential to trigger robust and sustained, systemic and mucosal protective immunity against rapidly evolving SARS-CoV2 variants.
Topics & Concepts
Immune systemImmunologyVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Dendritic cellBiologyCoronavirus disease 2019 (COVID-19)MedicineDiseasePathologyInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchImmunotherapy and Immune ResponsesAnimal Virus Infections Studies