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Design, synthesis, molecular docking and biological evaluation of 1,3,5-trisubstituted-1H-pyrazole derivatives as anticancer agents with cell cycle arrest, ERK and RIPK3- kinase activities

Nader M. Boshta, Ahmed Temirak, Zeinab A. Elshahid, Zahid Shafiq, Ahmed A. F. Soliman

2023Bioorganic Chemistry20 citationsDOI

Topics & Concepts

KinaseChemistryPyrazoleMAPK/ERK pathwayDocking (animal)Cell cycle checkpointCell cycleCytotoxicityBiochemistryCell biologyIn vitroCellStereochemistryBiologyMedicineNursingSynthesis and biological activityComputational Drug Discovery MethodsClick Chemistry and Applications
Design, synthesis, molecular docking and biological evaluation of 1,3,5-trisubstituted-1H-pyrazole derivatives as anticancer agents with cell cycle arrest, ERK and RIPK3- kinase activities | Litcius