Six-gene signature for predicting survival in patients with head and neck squamous cell carcinoma
Juncheng Wang, Xun Chen, Yuxi Tian, Gangcai Zhu, Yuexiang Qin, Xuan Chen, Leiming Pi, Ming Wei, Guancheng Liu, Zhexuan Li, Chang‐Han Chen, Yunxia Lv, Gengming Cai
Abstract
) were ultimately obtained through random forest feature selection. Cox regression analysis confirmed the 6-gene signature is an independent prognostic factor in HNSCC patients. This signature effectively stratified samples in the training, test, and external verification sets (P < 0.01). The 5-year survival AUC in the training and verification sets was greater than 0.74. Thus, we have constructed a 6-gene signature as a new prognostic marker for predicting survival of HNSCC patients.
Topics & Concepts
Head and neck squamous-cell carcinomaGene signatureOncologyRandom forestProportional hazards modelGeneInternal medicineSingle-nucleotide polymorphismSurvival analysisFeature selectionMedicineHead and neck cancerCancerComputational biologyBiologyComputer scienceGene expressionGenotypeArtificial intelligenceGeneticsRNA modifications and cancerCholangiocarcinoma and Gallbladder Cancer StudiesCancer-related molecular mechanisms research