Conformationally Constrained Glycosyl Donors as Tools to Control Glycosylation Outcomes
Robin Jeanneret, Simon E. Johnson, M. Carmen Galán
Abstract
The stereoselective synthesis of oligosaccharides remains one of the biggest challenges in carbohydrate chemistry. Many factors, including reaction conditions and the type of glycosyl donor and acceptor used, can affect the outcome of glycosylation reactions. In this Perspective, we discuss methods aimed to control the reactivity and stereoselectivity of glycosylation reactions using conformationally constrained glycosyl donors, with a focus on more recently developed chemistry.
Topics & Concepts
GlycosylationGlycosylGlycosyl donorStereoselectivityChemistryReactivity (psychology)Carbohydrate chemistryGlycosyltransferaseCombinatorial chemistryStereochemistryOrganic chemistryCatalysisBiochemistryEnzymeMedicineAlternative medicinePathologyCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchEnzyme Production and Characterization