Tandem isonitrile insertion/azacyclopropylidene-annulated cyclohexenone–tropone rearrangement of <i>p</i>-QMs and TosMIC: <i>de novo</i> synthesis of pyrrolotropones with anti-cancer activity
Chuan‐Hua Qu, Gui‐Ting Song, Jiuhong Huang, Run Qiu Huang, Yuan Chen, Tong Liu, Dianyong Tang, Zhigang Xu, Zhong‐Zhu Chen
Abstract
TosMIC causes ring expansion of p -QMs: highly substituted pyrrolotropones are rapidly assembled in a domino process mediated by DBU. The utility of the method was highlighted by follow-up transformation and biological activity identification.
Topics & Concepts
ChemistryTroponeDominoRing (chemistry)Combinatorial chemistryStereochemistryCascade reactionOrganic chemistryCatalysisOxidative Organic Chemistry ReactionsSynthetic Organic Chemistry MethodsMarine Sponges and Natural Products