pH-Sensitive nanodiamond co-delivery of retinal and doxorubicin boosts breast cancer chemotherapy
Jicheng Cui, Bo Hu, Yuejun Fu, Zhengkun Xu, Yingqi Li
Abstract
demonstrated that the NPA@D was mainly accumulated in the tumor site rather than any other organ by intraperitoneal injection after 24 h, in which the fluorescence intensity of NPA@D was 19 times that of the free DOX, suggesting that a far reduced off-target effect and side effects would be expected. Therefore, this work presents a new paradigm for improving chemotherapy and reversing drug resistance using the ND platform for co-delivery of DOX and ATR.
Topics & Concepts
NanodiamondDoxorubicinBreast cancerChemotherapyRetinalCancer researchChemistryMedicineCancerInternal medicineBiochemistryOrganic chemistryDiamondNanoplatforms for cancer theranosticsDiamond and Carbon-based Materials ResearchNanoparticle-Based Drug Delivery