Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics
Sujata Chakraborty, Ethan Ahler, Jessica J. Simon, Linglan Fang, Zachary E. Potter, Katherine A. Sitko, Jason J. Stephany, Miklós Guttman, Douglas M. Fowler, Dustin J. Maly
Topics & Concepts
Protein kinase domainProto-oncogene tyrosine-protein kinase SrcKinaseBiologyDrug resistanceBiochemistryCell biologyComputational biologyChemistryMutantGeneticsGeneComputational Drug Discovery MethodsMelanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling