Diagnostic Accuracy of Pre-Transcatheter Aortic Valve Replacement Nitroglycerin-Free Fractional Flow Reserve-Computed Tomography-Based Physiological Assessment in Patients With Severe Aortic Stenosis for Predicting Post-Transcatheter Aortic Valve Replacement Ischemia
Satoru Sasaki, Hiroyuki Kawamori, Takayoshi Toba, Ryo Takeshige, Yusuke Fukuyama, Takashi Hiromasa, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Toshiro Shinke, Ken–ichi Hirata, Hiromasa Otake
Abstract
BACKGROUND: ) has not been validated in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) for coronary artery disease due to theoretical difficulties in using nitroglycerin for such patients. METHODS AND RESULTS: to indicate post-TAVR FFR ≤0.80, with an area under the curve (AUC) of 0.84, and the counterpart cutoff of pre-TAVR iFR was 0.89 with an AUC of 0.86. CONCLUSIONS: without nitroglycerin could be a useful non-invasive imaging modality for assessing the severity of coronary artery lesions in patients with severe AS.