EZH2 inhibition sensitizes MYC-high medulloblastoma cancers to PARP inhibition by regulating NUPR1-mediated DNA repair
Jianzhong Yu, Jichang Han, Yu Meng, Huanwen Rui, An Sun, Hao Li
Topics & Concepts
Cancer researchBiologyEZH2Poly ADP ribose polymeraseMedulloblastomaDNA repairPARP inhibitorDNA damagePARP1Synthetic lethalityGenome instabilityDownregulation and upregulationDNAHistoneGeneticsGenePolymeraseGlioma Diagnosis and TreatmentDNA Repair MechanismsPARP inhibition in cancer therapy