SARS-CoV-2 targets the lysosome to mediate airway inflammatory cell death
Xiao Sun, Jun Yu, Sunny H. Wong, Matthew T.V. Chan, Lin Zhang, William Ka Kei Wu
Abstract
ATP6AP1: ATPase H+ transporting accessory protein 1; CASP1: caspase 1; COVID-19: coronavirus disease 2019; GSDMD: gasdermin D; IL1B: interleukin 1 beta; IL18: interleukin 18; KRT 18: keratin 18; NLRP3: NLR family pyrin domain containing 3; NOD: nucleotide oligomerization domain; NSP6: non-structural protein 6; TFEB: transcription factor EB; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.
Topics & Concepts
LysosomeBiologyAutophagyProgrammed cell deathSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)InflammationTFEB2019-20 coronavirus outbreakImmunologyVirologyCell biologyApoptosisGeneticsMedicinePathologyDiseaseInfectious disease (medical specialty)BiochemistryEnzymeOutbreakInflammasome and immune disordersDermatological and COVID-19 studiesCalcium signaling and nucleotide metabolism