TRAM1 protein may support ER protein import by modulating the phospholipid bilayer near the lateral gate of the Sec61-channel
Marie-Christine Klein, Monika Lerner, Duy Nguyen, Stefan Pfeffer, Johanna Dudek, Friedrich Förster, Volkhard Helms, Sven Lang, Richard Zimmermann
Abstract
ER, endoplasmic reticulum; OST, oligosaccharyltransferase; RAMP, ribosome-associated membrane protein; SP, signal peptide; SR, SRP-receptor; SRP, signal recognition particle; TMH, signal peptide-equivalent transmembrane helix; TRAM, translocating chain-associated membrane protein; TRAP, translocon-associated protein.
Topics & Concepts
Channel (broadcasting)Lipid bilayerPhospholipidBilayerBiophysicsTransloconChemistryCell biologyMaterials scienceMembrane proteinComputer scienceBiologyMembraneBiochemistryTelecommunicationsRNA and protein synthesis mechanismsViral Infections and Immunology ResearchIon channel regulation and function