<i>In Vitro</i> Assessment of Antimicrobial Resistance Dissemination Dynamics during Multidrug-Resistant-Bacterium Invasion Events by Using a Continuous-Culture Device
Ziyun Li, Lulu Shi, Bianfang Wang, Wei Xin, Jian Zhang, Tingting Guo, Jian Kong, Mingyu Wang, Hai Xu
Abstract
community. Using this novel tool, we provide evidence on the drivers of antimicrobial resistance dissemination, on the detrimental impact of environmental antibiotic contamination, and on the danger of antimicrobial resistance in hospitals, even if what harbors the antimicrobial resistance is not a pathogen. This work furthers our understanding of antimicrobial resistance and its dissemination between bacteria and of antibiotic therapy, our most powerful tool against bacterial infection.
Topics & Concepts
AntimicrobialHorizontal gene transferAntibiotic resistanceMultiple drug resistanceBacteriaBiologyMicrobiologyGene transferGeneDrug resistanceGeneticsGenomePharmaceutical and Antibiotic Environmental ImpactsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and Efficacy