Polyoxometalates as Effective Nano-inhibitors of Amyloid Aggregation of Pro-inflammatory S100A9 Protein Involved in Neurodegenerative Diseases
Himanshu Chaudhary, Igor A. Iashchishyn, Nina V. Romanova, Mark A. Rambaran, Greta Musteikytė, Vytautas Smirnovas, Michael Holmboe, C. André Ohlin, Željko M. Svedružić, Ludmilla A. Morozova‐Roche
Abstract
of ca. 2.5 μM. We suggest that the region, including Lys 50 to Lys 54 and characterized by high amyloid propensity, could be the key sequences involved in S1009 amyloid self-assembly. The inhibition and complete hindering of S100A9 amyloid pathways may be used in the therapeutic applications targeting the amyloid-neuroinflammatory cascade in neurodegenerative diseases.
Topics & Concepts
BiophysicsCircular dichroismAmyloid (mycology)ChemistryProtein secondary structurePeptideBiochemistryBiologyInorganic chemistryAlzheimer's disease research and treatmentsS100 Proteins and AnnexinsCholinesterase and Neurodegenerative Diseases