Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models
Gabriel González, Jiří Hodoň, Anna N. Kazakova, Cosimo Walter D’Acunto, Petr Kaňovský, Milan Urban, Miroslav Strnad
Topics & Concepts
NeuroprotectionChemistryNeurodegenerationOxidative stressMitochondrial permeability transition poreGlutamate receptorRotenonePharmacologySH-SY5YBiochemistryCytotoxicityStereochemistryProgrammed cell deathMitochondrionApoptosisCell cultureIn vitroBiologyInternal medicineReceptorMedicineNeuroblastomaDiseaseGeneticsNatural product bioactivities and synthesisMedicinal Plants and NeuroprotectionAlzheimer's disease research and treatments