The Rab32/BLOC-3–dependent pathway mediates host defense against different pathogens in human macrophages
Massimiliano Baldassarre, Virtu Solano-Collado, Arda Balci, Rosa A. Colamarino, Ivy M. Dambuza, Delyth M. Reid, Heather M. Wilson, Gordon D. Brown, Subhankar Mukhopadhyay, Gordon Dougan, Stefania Spanò
Abstract
pathogenicity island-1-encoded type III secretion system. These findings demonstrate that the Rab32/BLOC-3 pathway is a novel and universal host-defense pathway and protects mammalian species from various pathogens.
Topics & Concepts
Small GTPaseHost (biology)AntimicrobialMicrobiologyGTPaseBiologyCell biologyChemistrySignal transductionEcologyBacterial biofilms and quorum sensingBacterial Genetics and BiotechnologyAntibiotic Resistance in Bacteria