Mechanism of C-type inactivation in the hERG potassium channel
Jing Li, Rong Shen, Bharat Reddy, Eduardo Perozo, Benoı̂t Roux
Abstract
channels suggests that C-type inactivation depends on the degree of opening of the intracellular gate via the filter-gate allosteric coupling.
Topics & Concepts
hERGMechanism (biology)Potassium channelChemistryPotassium channel blockerPharmacologyChannel (broadcasting)Cell biologyBiophysicsBiologyComputer scienceComputer networkEpistemologyPhilosophyCardiac electrophysiology and arrhythmiasIon channel regulation and functionNeuroscience and Neuropharmacology Research