Glibenclamide attenuates 2,5-hexanedione-induced neurotoxicity in the spinal cord of rats through mitigation of NLRP3 inflammasome activation, neuroinflammation and oxidative stress
Liyan Hou, Jie Yang, Sheng Li, Ruixue Huang, Dongdong Zhang, Jie Zhao, Qingshan Wang
Topics & Concepts
InflammasomeGlibenclamideNeurotoxicityOxidative stressNeuroinflammationPharmacologyChemistryMalondialdehydeSpinal cordGlutathioneEndocrinologyMedicineInflammationInternal medicineBiochemistryDiabetes mellitusToxicityReceptorEnzymePsychiatryInflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideNeuroinflammation and Neurodegeneration Mechanisms