Eat or Be Eaten: Strategies Used by <i>Legionella</i> to Acquire Host-Derived Nutrients and Evade Lysosomal Degradation
Stephanie R. Shames
Abstract
genome to accommodate a massive repertoire of effector proteins that promote LCV biogenesis, safeguard the LCV from endolysosomal maturation, and mediate the acquisition of host nutrients. This minireview is focused on the mechanisms by which an ancient intracellular pathogen leverages effector proteins and hijacks host cell biology to obtain essential host-derived nutrients and prevent lysosomal degradation.
Topics & Concepts
BiologyEffectorLegionella pneumophilaLegionellaBiogenesisHost (biology)Intracellular parasiteEndocytic cycleVacuoleCell biologyMicrobiologySecretionIntracellularBacteriaGeneticsCellGeneEndocytosisCytoplasmBiochemistryLegionella and Acanthamoeba researchNeutrophil, Myeloperoxidase and Oxidative MechanismsVibrio bacteria research studies