CAR-T cells based on a TCR mimic nanobody targeting HPV16 E6 exhibit antitumor activity against cervical cancer
Zhijian Duan, Dan Li, Nan Li, Shaoli Lin, Hua Ren, Jessica Hong, Christian S. Hinrichs, Mitchell Ho
Abstract
, through activation of nuclear factor of activated T cells (NFAT) and nuclear factor κB (NF-κB) signaling. Importantly, F5 CAR-T cells inhibited the growth of CaSki and SS4050 tumor xenografts in mice. These findings demonstrate that HPV-16+ cervical cancer can be targeted by F5 nanobody-based CAR-T cells, offering a valuable alternative strategy for treating HPV-16+ malignancies.
Topics & Concepts
NFATNF-κBCancer researchChemistrySignal transductionNFKB1Cervical cancerCell biologyVirologyCancerBiologyGeneTranscription factorGeneticsBiochemistryCAR-T cell therapy researchImmunotherapy and Immune ResponsesImmune Cell Function and Interaction