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Hot-melt extrudability of amorphous solid dispersions of flubendazole-copovidone: An exploratory study of the effect of drug loading and the balance of adjuvants on extrudability and dissolution

João Matheus Cassiano De Assis, Eduardo José Barbosa, Vinícius Danilo Nonato Bezzon, Felipe Rebello Lourenço, Flavio M. S. Carvalho, J. R. Matos, Nádia Araci Bou‐Chacra, Chris J. Benmore, Stephen R. Byrn, Fanny Nascimento Costa, Gabriel Lima Barros de Araújo

2022International Journal of Pharmaceutics22 citationsDOIOpen Access PDF

Topics & Concepts

Magnesium stearateExtrusionDifferential scanning calorimetryDissolutionMaterials scienceSolubilityDissolution testingAmorphous solidCrystallinityDosage formChemical engineeringHydroxypropyl cellulosePharmacologyChromatographyEthyl celluloseChemistryPolymerOrganic chemistryMedicineComposite materialThermodynamicsEngineeringPhysicsMicroencapsulation and Drying ProcessesAdvancements in Transdermal Drug DeliveryDrug Solubulity and Delivery Systems
Hot-melt extrudability of amorphous solid dispersions of flubendazole-copovidone: An exploratory study of the effect of drug loading and the balance of adjuvants on extrudability and dissolution | Litcius