Litcius/Paper detail

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

Kenneth H. Dinnon, Sarah R. Leist, Alexandra Schäfer, Caitlin E. Edwards, David R. Martinez, Stephanie A. Montgomery, Ande West, Boyd L. Yount, Yixuan J. Hou, Lily E. Adams, Kendra L. Gully, Ariane J. Brown, Emily Huang, Matthew D. Bryant, Ingrid Choong, Jeffrey S. Glenn, Lisa E. Gralinski, Timothy P. Sheahan, Ralph S. Baric

2020Nature686 citationsDOIOpen Access PDF

Topics & Concepts

Genetically modified mouseVirologyCoronavirusViral replicationBiologyVirusTransgeneVero cellPhenotypeInterferonIn vivoImmune systemRodentImmunologyRecombinant DNADiseaseCoronavirus disease 2019 (COVID-19)MedicineGeneInfectious disease (medical specialty)GeneticsEcologyPathologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studiesinterferon and immune responses