Recent Developments on Five-Component Reactions
Xiaoming Ma, Sanjun Zhi, Wei Zhang
Abstract
Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in this review article are the recent development on 5-compoment reactions (5CRs) of the following six types: (I) five different molecules A + B + C + D + E; pseudo-5CRs including (II) 2A + B + C + D, (III) 2A + 2B + C, (IV) 3A + B + C, (V) 3A + 2B, and (VI) 4A + B. 5CRs with more than five-reaction centers are also included.
Topics & Concepts
Atom economyComponent (thermodynamics)ChemistryCombinatorial chemistryReaction conditionsComputer scienceBiochemical engineeringCatalysisOrganic chemistryEngineeringPhysicsThermodynamicsMulticomponent Synthesis of HeterocyclesSynthesis of Tetrazole DerivativesChemical Synthesis and Analysis