Multifunctional Ca–Zn–Si-based micro-nano spheres with anti-infective, anti-inflammatory, and dentin regenerative properties for pulp capping application
Zhengmao Li, Kunke Xie, Shuang Yang, Ting Yu, Yin Xiao, Yinghong Zhou
Abstract
, macrophages showed a significant decrease of pro-inflammatory M1 markers compared with the undoped BG group. It is also noted that the conditioned medium derived from BGz-stimulated macrophages could significantly promote mineralized dentin formation of dental pulp cells (DPCs). In rats, acute pulp restoration experiments proved that BGz used as a pulp capping agent had excellent dentin regenerative properties. This work may provide a novel strategy to promote osteo/dentinogenic differentiation through regulating early inflammation, with potential applications in pulp capping.
Topics & Concepts
Materials sciencePulp (tooth)Pulp cappingNano-DentinComposite materialChemical engineeringNanotechnologyDentistryEngineeringMedicineEndodontics and Root Canal TreatmentsDental materials and restorationsBone Tissue Engineering Materials