OligoTRAFTACs: A generalizable method for transcription factor degradation
Kusal T. G. Samarasinghe, Elvira An, Miriam A. Genuth, Ling Chu, Scott A. Holley, Craig M. Crews
Abstract
Targeted transcription factor degradation using oligonucleotide-based transcription factor targeting chimeras (TRAFTACs).
Topics & Concepts
BrachyuryTranscription factorComputational biologyBiologyZebrafishUbiquitin ligaseCell biologyGeneGeneticsUbiquitinEmbryonic stem cellMesodermProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysGenomics and Chromatin Dynamics