New Validated Method for the Determination of Six Opium Alkaloids in Poppy Seed-Containing Bakery Products by High-Performance Liquid Chromatography-Tandem Mass Spectrometry after Magnetic Solid-Phase Extraction
Gema Casado‐Hidalgo, Gonzalo Martínez‐García, Sonia Morante‐Zarcero, Damián Pérez‐Quintanilla, Isabel Sierra
Abstract
@TPA-Fe] was used for a fast magnetic solid-phase extraction. The method has been validated with adequate recoveries (70-110%) and relative standard deviations (<20%) and without matrix effects. Nine bakery samples (five breadsticks and four sliced bread) were analyzed; breadsticks showed low amounts of OAs, but two sliced bread showed higher amounts of OAs than the new amount (1.5 mg/kg) set by the Commission Regulation (EU) 2021/2142.
Topics & Concepts
PapaverChromatographyExtraction (chemistry)PoppyChemistryMass spectrometrySolid phase extractionTandem mass spectrometryLiquid chromatography–mass spectrometryBotanyBiologyBerberine and alkaloids researchPlant-based Medicinal ResearchAlkaloids: synthesis and pharmacology