Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression
Norie Sugitani, Frank P. Vendetti, Andrew J. Cipriano, Pinakin Pandya, Joshua J. Deppas, Tatiana N. Moiseeva, Sandra Schamus-Haynes, Yiyang Wang, Drake Palmer, Hatice U. Osmanbeyoglu, Anna Bostwick, Nathaniel W. Snyder, Yi‐Nan Gong, Katherine M. Aird, Greg M. Delgoffe, Jan H. Beumer, Christopher J. Bakkenist
Abstract
T cell-dependent anti-tumor responses in mouse models. We conclude that ATR is essential to limit dU contamination in genomic DNA and IFN-α/β expression.
Topics & Concepts
ThymidineDeoxyuridineThymidine kinaseDNAgenomic DNAInterferonBiologyMolecular biologyChemistryKinaseCancer researchCell biologyVirologyBiochemistryVirusHerpes simplex virusDNA Repair MechanismsCancer-related Molecular PathwaysCell death mechanisms and regulation