Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube
Huy Q. Dinh, Xianzhi Lin, Forough Abbasi, Robbin Nameki, Marcela Haro, Claire Olingy, Heidi Chang, Lourdes Hernández, Simon A. Gayther, Kelly N. Wright, Paul‐Joseph Aspuria, Beth Y. Karlan, Rosario I. Corona, Andrew Li, B.J. Rimel, Matthew T. Siedhoff, Fabíola Medeiros, Kate Lawrenson
Abstract
), a group known to have particularly poor prognoses. This cellular and molecular compendium of the human fallopian tube in cancer-free women is expected to advance our understanding of the earliest stages of fallopian epithelial neoplasia.
Topics & Concepts
TranscriptomeCarcinogenesisFallopian tubeBiologyGene expressionGeneCell biologyGeneticsGene expression profilingCellular differentiationComputational biologyAnatomyOvarian cancer diagnosis and treatment