GPX4 inhibition synergistically boosts mitochondria targeting nanoartemisinin-induced apoptosis/ferroptosis combination cancer therapy
Hui Yu, Jia‐Mi Li, Kai Deng, Wei Zhou, Kun‐Heng Li, Caixia Wang, Qian Wang, Meng Wu, Shi‐Wen Huang
Abstract
enhancing ferroptosis. The synergistic anticancer activity of artemisinin and RSL3 in the mitochondria not only improves cancer cell-killing ability, but also inhibits the re-proliferation of residual cancer cells. This study provides a new insight into developing highly efficient and practical artemisinin nanomedicines for cancer therapy.
Topics & Concepts
ArtemisininCancer cellApoptosisChemistryMitochondrionReactive oxygen speciesPharmacologyCancerCombination therapyCancer researchBiochemistryBiologyImmunologyPlasmodium falciparumGeneticsMalariaDrug Transport and Resistance MechanismsAdvanced biosensing and bioanalysis techniquesPeptidase Inhibition and Analysis