Lymph-Node-Targeted Cholesterolized TLR7 Agonist Liposomes Provoke a Safe and Durable Antitumor Response
Dandan Wan, Haiying Que, Li Chen, Tianxia Lan, Weiqi Hong, He Cai, H. J. Yang, Yuquan Wei, Xiawei Wei
Abstract
T cell responses. Furthermore, 1V209-Cho-Lip induced tumor-specific memory immunity to inhibit cancer recurrence and metastasis. These results indicate that cholesterol conjugation with 1V209 is an effective approach to target lymph nodes and to reduce the adverse effects. This work provides a rational basis for the distribution optimization of TLR agonists for potential clinical use.
Topics & Concepts
MedicineAgonistTLR7Cancer researchCancerMetastasisLymphImmunotherapyLymph nodeLiposomeImmune systemPharmacologyInternal medicineInnate immune systemReceptorImmunologyToll-like receptorChemistryPathologyBiochemistryImmunotherapy and Immune ResponsesImmune Response and InflammationRNA Interference and Gene Delivery