Synergistic nanoplatform of M1 macrophage-derived extracellular vesicles and MoS <sub>2</sub> for tumor-targeted photoimmunotherapy in bladder cancer
Andrew E-Y Chuang, Yu-Kuang Tao, Yu‐Jui Fan, Hung-Jui Chiu, Lekshmi Rethi, Chia‐Hung Liu
Abstract
M1 macrophage-derived EVs engineered with MoS 2 enable tumor-targeted photothermal-immunotherapy, suppressing bladder cancer via potential CD8 + T-cell activation, PD-L1 reduction, and ROS generation under NIR irradiation. Created in BioRender. Chuang, A. (2025) https://BioRender.com/ct5w2pa.
Topics & Concepts
Photothermal therapyImmunotherapyExtracellular vesiclesCancer researchCancer immunotherapyBladder cancerCancerCD8MacrophageMedicineMaterials scienceChemistryNanotechnologyAntigenImmunologyBiologyCell biologyInternal medicineIn vitroBiochemistryNanoplatforms for cancer theranosticsExtracellular vesicles in diseaseImmune cells in cancer