Deep and compact dentinal tubule occlusion <i>via</i> biomimetic mineralization and mineral overgrowth
Zhuo Chen, Yuyan Duan, Songzhe Shan, Kaida Sun, Gang Wang, Changyu Shao, Zhenhang Tang, Zekai Xu, Yanyan Zhou, Zhi Chen, Ruikang Tang, Haihua Pan, Zhijian Xie
Abstract
Dentinal tubule (DT) occlusion by desensitizing agents has been widely applied to inhibit the transmission of external stimuli that cause dentin hypersensitivity (DH). However, most desensitizing agents merely accomplish porous blocking or the formation of a superficial tubular occlusion layer, resulting in a lack of mechanical and acid resistance and long-term stability. Herein, combining biomimetic mineralization and mineral overgrowth of the dentinal matrix was shown to effectively occlude DTs, resulting in the formation of a compact and deep occluding mineral layer that is strongly bound to the organic matrix on tubule walls. This DT occlusion method could achieve both mechanical resistance and acid resistance, demonstrating the potential of an inexpensive, long-term, and efficient therapy for treating DH.