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Polyphyllin D punctures hypertrophic lysosomes to reverse drug resistance of hepatocellular carcinoma by targeting acid sphingomyelinase

Yang Wang, Yanyan Chen, Gui‐Bin Gao, Yang-Han Zheng, Nan‐Nan Yu, Lan Ouyang, Xuejuan Gao, Nan Li, Shiyuan Wen, Shangjia Huang, Qian Zhao, Langxia Liu, Mingrong Cao, Shuixing Zhang, Jing Zhang, Qing‐Yu He

2023Molecular Therapy33 citationsDOIOpen Access PDF

Topics & Concepts

LysosomeAutophagyCeramidePhospholipidosisAcid sphingomyelinasePharmacologySphingomyelinCancer cellCancer researchBiologyChemistryBiochemistryCancerApoptosisPhospholipidEnzymeGeneticsMembraneAutophagy in Disease and TherapySphingolipid Metabolism and SignalingCalcium signaling and nucleotide metabolism
Polyphyllin D punctures hypertrophic lysosomes to reverse drug resistance of hepatocellular carcinoma by targeting acid sphingomyelinase | Litcius