Design and Synthesis of DDR1 Inhibitors with a Desired Pharmacophore Using Deep Generative Models
Atsushi Yoshimori, Yasunobu Asawa, Enzo Kawasaki, Tomohiko Tasaka, Seiji Matsuda, Toru Sekikawa, Satoshi Tanabe, Masahiro Neya, Hideaki Natsugari, Chisato Kanai
Abstract
Abstract Discoidin domain receptor 1 (DDR1) inhibitors with a desired pharmacophore were designed using deep generative models (DGMs). DDR1 is a receptor tyrosine kinase activated by matrix collagens and implicated in diseases such as cancer, fibrosis and hypoxia. Herein we describe the synthesis and inhibitory activity of compounds generated from DGMs. Three compounds were found to have sub‐micromolar inhibitory activity. The most potent of which, compound 3 ( N ‐(4‐chloro‐3‐((pyridin‐3‐yloxy)methyl)phenyl)‐3‐(trifluoromethyl)benzamide), had an IC 50 value of 92.5 nM. Furthermore, these compounds were predicted to interact with DDR1, which have a desired pharmacophore derived from a known DDR1 inhibitor. The results of synthesis and experiments indicated that our de novo design strategy is practical for hit identification and scaffold hopping.