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Micelle enabled C(sp<sup>2</sup>)–C(sp<sup>3</sup>) cross-electrophile coupling in water <i>via</i> synergistic nickel and copper catalysis

Ning Ye, Bin Wu, Kangming Zhao, Xiaobin Ge, Yu Zheng, Xiaodong Shen, Lei Shi, Margery Cortes‐Clerget, Morgan Regnier, Michaël Parmentier, Fabrice Gallou

2021Chemical Communications17 citationsDOI

Abstract

A robust and sustainable C(sp2)-C(sp3) cross-electrophile coupling was developed via nickel/copper synergistic catalysis under micellar conditions. This protocol provided a general method to access alkylated arenes with good to excellent yields on a very large scale.

Topics & Concepts

NickelCopperCatalysisElectrophileChemistryMicelleCoupling (piping)Physical chemistryMaterials scienceOrganic chemistryMetallurgyAqueous solutionCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms
Micelle enabled C(sp<sup>2</sup>)–C(sp<sup>3</sup>) cross-electrophile coupling in water <i>via</i> synergistic nickel and copper catalysis | Litcius