Nitric Oxide Impacts Human Gut Microbiota Diversity and Functionalities
Marion Leclerc, Cassandre Bedu-Ferrari, Lucie Etienne‐Mesmin, Mahendra Mariadassou, Lucie Lebreuilly, Seav‐Ly Tran, Laurence Brazeau, Camille Mayeur, Julien Delmas, Olivier Rué, Sylvain Denis, Stéphanie Blanquet‐Diot, Nalini Ramarao
Abstract
fermentation systems with human fecal samples to understand the effect of NO on the microbiota: NO modified the microbial composition and its functionality. High NO concentration depleted the microbiota of beneficial butyrate-producing species and favored potentially deleterious species (E. coli, E. faecalis, and P. mirabilis), which we showed can sustain high NO concentrations. Our work shows that NO may participate in the vicious circle of inflammation, leading to detrimental and irreversible consequences on human health.