Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation <i>via</i> the ROS/autophagy signaling pathway
Fang Chen, Chengnan Chu, Xinyu Wang, Chao Yang, Yunxuan Deng, Zehua Duan, Kai Wang, Baochen Liu, Wu Ji, Weiwei Ding
Abstract
: Taken together, these findings suggest that HES may inhibit NET formation in a ROS/autophagy-dependent manner and switch neutrophil death from NETosis to apoptosis, which reduced NETs-related intestinal barrier damage, providing a novel protective role in intestinal barrier dysfunction during sepsis.
Topics & Concepts
Neutrophil extracellular trapsAutophagyCell biologyChemistrySepsisExtracellularTrap (plumbing)Signal transductionHesperetinIntracellularInflammationImmunologyMedicineBiologyBiochemistryApoptosisEnvironmental engineeringFlavonoidAntioxidantEngineeringNeutrophil, Myeloperoxidase and Oxidative MechanismsAdvanced Glycation End Products researchInflammasome and immune disorders