Development, Molecular Docking, and <i>In Silico</i> ADME Evaluation of Selective ALR2 Inhibitors for the Treatment of Diabetic Complications <i>via</i> Suppression of the Polyol Pathway
Aqeel Imran, Muhammad Tariq Shehzad, Syed Jawad Ali Shah, Mark Laws, Taha Al‐Adhami, Khondaker Miraz Rahman, Imtiaz Ali Khan, Zahid Shafiq, Jamshed Iqbal
Abstract
as a drug candidate with promising antioxidant and antiglycative properties that may be useful for the treatment of diabetic complications through selective inhibition of ALR2.
Topics & Concepts
Aldose reductasePolyol pathwayMethylglyoxalChemistryPharmacologyADMEGlycationAldehyde ReductaseAntioxidantAldose reductase inhibitorBiochemistryIn silicoOxidative stressDocking (animal)EnzymeMedicineIn vitroReceptorGeneNursingAldose Reductase and TaurineEicosanoids and Hypertension PharmacologyPharmacology and Obesity Treatment