FADS1 overexpression promotes fatty acid synthesis and triacylglycerol accumulation <i>via</i> inhibiting the AMPK/SREBP1 pathway in goat mammary epithelial cells
Jiangtao Huang, Yuexin Shao, Xueyang Zong, Huawen Zhang, Xian Zhang, Zhifei Zhang, Huaiping Shi
Abstract
). It also significantly promoted the SREBP1 nuclear translocation by inhibiting the AMPK activation. In addition, FADS1 overexpression inhibited cell proliferation and arrested cell cycle at the G1 phase. These findings reveal a novel FADS1-AMPK-SREBP1 pathway regulating milk fat production in the goat mammary gland.
Topics & Concepts
Sterol regulatory element-binding proteinPolyunsaturated fatty acidAMPKTriglycerideFatty acid synthesisBiochemistryLipid metabolismFatty acidBiologyChemistryEndocrinologyCholesterolEnzymeSterolProtein kinase ACancer, Lipids, and MetabolismLipid metabolism and biosynthesisCancer, Hypoxia, and Metabolism