A twin histidine motif is the core structure for high-affinity substrate selection in plant ammonium transporters
Pascal Ganz, Toyosi Ijato, Romano Porras-Murrilo, Nils Stührwohldt, Uwe Ludewig, Benjamin Neuhäuser
Abstract
We conclude that optimization for ammonium transport in plant AMT represents a compromise between substrate deprotonation for optimal selectivity and high substrate affinity and transport rates.
Topics & Concepts
DeprotonationMethylamineAmmoniumPermeaseChemistryHistidineSelectivityBiochemistryStereochemistryMutantOrganic chemistryEnzymeGeneIonCatalysisPlant nutrient uptake and metabolismPolyamine Metabolism and ApplicationsIon channel regulation and function