Designing Cobalt(II) Complexes for Tandem Dehydrogenative Synthesis of Quinoline and Quinazoline Derivatives
Debjyoti Pal, Avijit Mondal, Rajashri Sarmah, Dipankar Srimani
Abstract
In this work, we have constructed three new Co(II) complexes in which steric features govern their structural geometry. The metal ligand-cooperation behavior of the alkoxy arm is utilized to explore the catalytic activities of these complexes with respect to dehydrogenation. A wide range of C-3-substituted quinoline and quinazoline derivatives were synthesized in high yields. The developed protocol's usefulness is enhanced by the chemoselective transformation of different fatty alcohols to synthesize heterocycles having distal unsaturation. Various kinetic, mechanistic, and control studies were conducted to comprehend the reaction route.
Topics & Concepts
ChemistryQuinolineDehydrogenationCombinatorial chemistrySteric effectsCatalysisLigand (biochemistry)TandemCobaltDegree of unsaturationQuinazolineAlkoxy groupStereochemistryOrganic chemistryAlkylReceptorMaterials scienceBiochemistryComposite materialAsymmetric Hydrogenation and CatalysisQuinazolinone synthesis and applicationsCarbon dioxide utilization in catalysis