Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3 <sup>+</sup> CD8 <sup>+</sup> T <sub>regs</sub>
Thorsten Joeris, Cristina Gómez‐Casado, Petra Holmkvist, Simon J. Tavernier, Aarón Silva-Sánchez, Luisa Klotz, Troy D. Randall, Allan McI. Mowat, Knut Kotarsky, Bernard MALISSEN, William W. Agace
Abstract
Intestinal cDC1 drive the generation of FoxP3 + CD8 + T regs to maintain tolerance to epithelial-derived self-antigen.
Topics & Concepts
AntigenFOXP3CD8BiologyCell biologyMolecular biologyImmunologyImmune systemImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses