Microphysiological pancreas-on-chip platform with integrated sensors to model endocrine function and metabolism
Katharina Schlünder, Madalena Cipriano, Aline Zbinden, Stefanie Fuchs, Torsten Mayr, Katja Schenke‐Layland, Peter Loskill
Abstract
specific changes in oxygen consumption due to higher metabolic activity of pseudo-islets at high glucose levels. To demonstrate applicability for drug testing, the effects of antidiabetic medications are assessed and changes in dynamic insulin secretion are observed in line with the respective mechanism of action. Finally, by integrating human pancreatic islet microtissues, we highlight the flexibility of the platform and demonstrate the preservation of long-term functionality of human endocrine pancreatic tissue.
Topics & Concepts
Endocrine systemPancreasOrgan-on-a-chipFunction (biology)Diabetes mellitusChipComputer scienceComputational biologyMedicineInternal medicineBiologyEndocrinologyCell biologyMaterials scienceNanotechnologyTelecommunicationsMicrofluidicsHormone3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis ApplicationsPancreatic function and diabetes