Palladium-Catalyzed Cross Haloalkynylation of Haloalkynes
Xiaoliang Ji, Jinli Nie, Xin Peng, Jinhui Hu, Xue-Tao Xu, Yubing Huang, Yibiao Li, Huanfeng Jiang
Abstract
Herein, we have developed a robust Pd-catalyzed haloalkynylation of haloalkynes for the synthesis of dihaloalkenyne derivatives. This cross-haloalkynylation reaction proceeds in a highly chemo- and regioselective manner under mild conditions in the presence of two slightly structurally different haloalkynes and shows strong functional group tolerance under ligand- and base-free conditions.
Topics & Concepts
ChemistryRegioselectivityPalladiumCatalysisFunctional groupLigand (biochemistry)Combinatorial chemistryBase (topology)Reaction conditionsOrganic chemistryReceptorBiochemistryPolymerMathematical analysisMathematicsCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsCatalytic Cross-Coupling Reactions