Copper-Catalyzed Single C–H Amination of 8-Aminoquinoline-Directed Ferrocenes
Kazuya Kanemoto, Nao Horikawa, Shun Hoshino, Yuichiro Tokoro, Shin‐ichi Fukuzawa
Abstract
An unprecedented copper-catalyzed C–H monoamination of ferrocenes directed by an 8-aminoquinoline amide directing group is described. This reaction proceeds in the presence of a catalytic amount of copper catalyst with both cyclic and acyclic amines to afford the various aminoferrocenes. The C–H amination of ortho-substituted ferroceneamides was also achieved, enabling rapid access to multisubstituted ferrocenes that are useful for developing new functional molecules.
Topics & Concepts
ChemistryAminationAmideCatalysisCopperCombinatorial chemistryFunctional groupMoleculeOrganic chemistryPolymerCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques