Bacteria-derived 3-hydroxydodecanoic acid induces a potent anti-tumor immune response via the GPR84 receptor
Egle Katkeviciutė, Anna Bircher, Rocío Sánchez, Martin Schwill, Andrea Dorst, Yasser Morsy, Javier Conde, Nicola Zamboni, Karl Gademann, Michael Scharl, Ana Montalban‐Arques
Abstract
T cell infiltration and cytotoxicity within tumor tissue in multiple cancer models. Metabolomics analysis of colorectal cancer patient serum reveals an inverse correlation between the abundance of these metabolites and advanced disease stages. Our findings provide a strong rationale for 3-hydroxydodecanoic acid and the GPR84 receptor to be considered as promising therapeutic targets for cancer treatment.
Topics & Concepts
Immune systemReceptorCancer researchCytotoxicityBacteriaCancer cellColorectal cancerCancerBiologyChemistryPharmacologyImmunologyBiochemistryMedicineInternal medicineIn vitroGeneticsGut microbiota and healthCancer Immunotherapy and BiomarkersCancer, Stress, Anesthesia, and Immune Response