Boosting the Osteogenic and Angiogenic Performance of Multiscale Porous Polycaprolactone Scaffolds by <i>In Vitro</i> Generated Extracellular Matrix Decoration
Betül Aldemir Dikici, Gwendolen C. Reilly, Frederik Claeyssens
Abstract
generated ECM on polymeric scaffolds resulted in higher angiogenic potential and a high degree of tissue infiltration. This study demonstrated that multiscale porous biohybrid scaffolds present a promising approach to improve bioactivity, encourage precursors to differentiate into mature bones, and to induce angiogenesis.
Topics & Concepts
PolycaprolactoneMaterials scienceBiomedical engineeringExtracellular matrixDecellularizationTissue engineeringMesenchymal stem cellScaffoldPorosityIn vivoNanotechnologyPolymerChemistryComposite materialCell biologyBiologyBiochemistryBiotechnologyMedicineBone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical ApplicationsTissue Engineering and Regenerative Medicine