Osilodrostat in Cushing's disease: The risk of delayed adrenal insufficiency should be carefully monitored
Frédéric Castinetti, Vincent Amodru, Thierry Brue
Abstract
Antisecretory data shows a highly effective and prolonged blockade of cortisol secretion with osilodrostat. The drawback is the occurrence of adrenal insufficiency (AI) in roughly a quarter of treated patients. In this short manuscript, we report three cases of atypical adrenal insufficiency with osilodrostat.
Topics & Concepts
Adrenal insufficiencyMedicineInternal medicineEndocrinologyPrimary Adrenal InsufficiencyHydrocortisoneAdrenocortical InsufficiencyPituitary Gland Disorders and TreatmentsAdrenal Hormones and DisordersGrowth Hormone and Insulin-like Growth Factors